HSP72 depletion suppresses γH2AX activation by genotoxic stresses via p53/p21 signaling
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چکیده
منابع مشابه
Signaling to the p53 Tumor Suppressor through Pathways Activated by Genotoxic and Non-genotoxic Stresses
The p53 tumor suppressor is a tetrameric transcription factor that is posttranslational modified at -1 8 different sites by phosphorylation, acetylation, or sumoylation in response to various cellular stress conditions. Specific posttranslational modifications, or groups of modifications, that result from the activation of different stress-induced signaling pathways are thought to modulate p53 ...
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Depletion of the major heat shock protein Hsp72 leads to activation of the senescence program in a variety of tumor cell lines via both p53-dependent and p53-independent pathways. Here, we found that the Hsp72-depleted cells show defect in phosphorylation and activation of the protein kinase Chk1 by genotoxic stresses, such as UVC irradiation or camptothecin. Under these conditions, phosphoryla...
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Genotoxic stresses such as DNA damage or abnormal chromosome segregation induced by various extrinsic or intrinsic factors often take place in all kinds of cells, which play important roles in tumorigenesis. Organisms have developed many molecular mechanisms regarding these genotoxic stresses during the evolutional progress. Protein postmodifications such as phosphorylation or sumoylation have ...
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ژورنال
عنوان ژورنال: Oncogene
سال: 2010
ISSN: 0950-9232,1476-5594
DOI: 10.1038/onc.2009.480